Author

Alejandro P. Heuck

University of Massachusetts - Cited by 3,094 - Pore-forming toxins - cholesterol biosensors

Biography

I am Alejandro P. Heuck, belonging to Departments of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA,USA. Interested in the field of Mitochondrial metabolism, Oxidative phosphorylation, Respiratory chain; Perfringolysin-O; Respirometry.
Title
Cited by
Year
Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier
AS Divakaruni, SE Wiley, GW Rogers, AY Andreyev, S Petrosyan, ...Proceedings of the national academy of sciences 110 (14), 5422-5427, 2013201
280
2013
Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin
R Ramachandran, AP Heuck, RK Tweten, AE JohnsonNature structural biology 9 (11), 823-827, 2002200
232
2002
Assembly and topography of the prepore complex in cholesterol-dependent cytolysins
AP Heuck, RK Tweten, AE JohnsonJournal of Biological Chemistry 278 (33), 31218-31225, 2003200
147
2003
Monomer-monomer interactions drive the prepore to pore conversion of a β-barrel-forming cholesterol-dependent cytolysin
EM Hotze, AP Heuck, DM Czajkowsky, Z Shao, AE Johnson, RK TwetenJournal of Biological Chemistry 277 (13), 11597-11605, 2002200
144
2002
Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding
JJ Flanagan, RK Tweten, AE Johnson, AP HeuckBiochemistry 48 (18), 3977-3987, 2009200
143
2009
The cholesterol-dependent cytolysin family of gram-positive bacterial toxins
AP Heuck, PC Moe, BB JohnsonCholesterol binding and cholesterol transport proteins: structure and …, 2010201
127
2010
Evidence for the “dock, lock, and latch” ligand binding mechanism of the staphylococcal microbial surface component recognizing adhesive matrix molecules (MSCRAMM) SdrG
MG Bowden, AP Heuck, K Ponnuraj, E Kolosova, D Choe, ...Journal of Biological Chemistry 283 (1), 638-647, 2008200
119
2008
Modifications in perfringolysin O domain 4 alter the cholesterol concentration threshold required for binding
BB Johnson, PC Moe, D Wang, K Rossi, BL Trigatti, AP HeuckBiochemistry 51 (16), 3373-3382, 2012201
92
2012
The SV40 late protein VP4 is a viroporin that forms pores to disrupt membranes for viral release
S Raghava, KM Giorda, FB Romano, AP Heuck, DN HebertPLoS pathogens 7 (6), e1002116, 2011201
64
2011
Conformational changes that effect oligomerization and initiate pore formation are triggered throughout perfringolysin O upon binding to cholesterol
AP Heuck, CG Savva, A Holzenburg, AE JohnsonJournal of Biological Chemistry 282 (31), 22629-22637, 2007200
59
2007
Perfringolysin O structure and mechanism of pore formation as a paradigm for cholesterol-dependent cytolysins
BB Johnson, AP HeuckMACPF/CDC proteins-agents of defence, attack and invasion, 63-81, 2014201
48
2014
A non-classical assembly pathway of Escherichia coli pore-forming toxin cytolysin A
M Fahie, FB Romano, C Chisholm, AP Heuck, M Zbinden, M ChenJournal of Biological Chemistry 288 (43), 310-31051, 2013201
42
2013
Phospholipid Hydrolysis Caused by Clostridium perfringens α-Toxin Facilitates the Targeting of Perfringolysin O to Membrane Bilayers
PC Moe, AP HeuckBiochemistry 49 (44), 9498-9507, 2010201
39
2010
Interaction of cholesterol with perfringolysin O: what have we learned from functional analysis?
SN Savinov, AP HeuckToxins 9 (12), 1, 2017201
38
2017
SV40 late protein VP4 forms toroidal pores to disrupt membranes for viral release
S Raghava, KM Giorda, FB Romano, AP Heuck, DN HebertBiochemistry 52 (22), 3939-3948, 2013201
37
2013
The transition from closed to open conformation of Treponema pallidum outer membrane-associated lipoprotein TP0453 involves membrane sensing and integration by two amphipathic …
A Luthra, G Zhu, DC Desrosiers, CH Eggers, V Mulay, A Anand, ...Journal of Biological Chemistry 286 (48), 41656-41668, 2011201
36
2011
Type 3 secretion translocators spontaneously assemble a hexadecameric transmembrane complex
FB Romano, Y Tang, KC Rossi, KR Monopoli, JL Ross, AP HeuckJournal of Biological Chemistry 291 (12), 6304-6315, 2016201
35
2016
Efficient Isolation of Pseudomonas aeruginosa Type III Secretion Translocators and Assembly of Heteromeric Transmembrane Pores in Model Membranes
FB Romano, KC Rossi, CG Savva, A Holzenburg, EM Clerico, AP HeuckBiochemistry 50 (33), 7117-7131, 2011201
28
2011
Mechanistic insights into the cholesterol-dependent binding of perfringolysin O-based probes and cell membranes
BB Johnson, M Breña, J Anguita, AP HeuckScientific Reports 7 (1), 13793, 2017201
27
2017
The Pseudomonas aeruginosa type III secretion translocator PopB assists the insertion of the PopD translocator into host cell membranes
Y Tang, FB Romano, M Breña, AP HeuckJournal of Biological Chemistry 293 (23), 8982-8993, 2018201
17
2018

Referred From: https://scholar.google.com/citations?user=Ox9GXUAAAAAJ&hl=en

Cited by
Citations 3094
h-index 25
i10-index 29
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