Author

Saverio Gentile

University of Illinois at Chicago - Cited by 1,028 - ion channels - cancer biology - hormone - neurodegeneration

Biography

Dr. Gentile was awarded his Ph.D. in 2002 from the Seconda Universita di Napoli, Italyl. In 2003 he moved to North Carolina, for a postdoc at the National Institute of Environmental Health Sciences, in the Laboratory of Neuroscience. In 2007, Dr. Gentile moved to Duke University in the Department of Cardiology Ion Channels Unit and in 2009 he accepted the position of Assistant Professor in the Department of Molecular Pharmacology and Therapeutics of the Loyola University Chicago.
Title
Cited by
Year
Voltage-gated ion channels in cancer cell proliferation
VR Rao, M Perez-Neut, S Kaja, S GentileCancers 7 (2), 849-875, 2015201
180
2015
A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRß, and genetic evidence for its role in the maturation of mouse hippocampal …
DLA Negin P. Martin, Ezequiel Marron Fernandez de Velasco, Fengxia Mizuno ...Endocrinology, 2013-2058, 201475201
75
2014
Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program
K Lansu, S GentileCell death & disease 4 (6), e652-e652, 2013201
59
2013
Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling
EK Breuer, D Fukushiro-Lopes, A Dalheim, M Burnette, J Zartman, S Kaja, ...Cell death & disease 10 (3), 180, 2019201
58
2019
Preclinical study of a Kv11. 1 potassium channel activator as antineoplastic approach for breast cancer
DF Fukushiro-Lopes, AD Hegel, V Rao, D Wyatt, A Baker, EK Breuer, ...Oncotarget 9 (3), 3321, 2018201
40
2018
(+)-Strebloside-induced cytotoxicity in ovarian cancer cells is mediated through cardiac glycoside signaling networks
WL Chen, Y Ren, J Ren, C Erxleben, ME Johnson, S Gentile, ...Journal of natural products 80 (3), 659-669, 2017201
37
2017
Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma
M Perez-Neut, L Haar, V Rao, S Santha, K Lansu, B Rana, WK Jones, ...Oncotarget 7 (16), 21991, 2016201
34
2016
Stimulation of hERG1 channel activity promotes a calcium-dependent degradation of cyclin E2, but not cyclin E1, in breast cancer cells
M Perez-Neut, A Shum, BD Cuevas, R Miller, S GentileOncotarget 6 (3), 1631, 2015201
27
2015
hERG1/Kv11. 1 activation stimulates transcription of p21waf/cip in breast cancer cells via a calcineurin-dependent mechanism
M Perez-Neut, VR Rao, S GentileOncotarget 7 (37), 58893, 2016201
26
2016
Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer
D Huang, S Chowdhury, H Wang, SR Savage, RG Ivey, JJ Kennedy, ...Cell Reports Medicine 2 (12), 2021202
15
2021
hERG1 potassium channel in cancer cells: a tool to reprogram immortality
S GentileEuropean Biophysics Journal 45, 649-655, 2016201
15
2016
Caveolin-1 controls mitochondrial damage and ROS production by regulating fission-fusion dynamics and mitophagy
Y Jiang, S Krantz, X Qin, S Li, H Gunasekara, YM Kim, A Zimnicka, M Bae, ...Redox Biology 52, 102304, 2022202
14
2022
MEKK2 regulates paxillin ubiquitylation and localization in MDA-MB 231 breast cancer cells
M Ameka, MP Kahle, M Perez-Neut, S Gentile, AA Mirza, BD CuevasBiochemical Journal 464 (1), 99-108, 202
14
2014
Repurposing Kir6/SUR2 channel activator minoxidil to arrests growth of gynecologic cancers
D Fukushiro-Lopes, AD Hegel, A Russo, V Senyuk, M Liotta, GC Beeson, ...Frontiers in Pharmacology 11, 577, 2020202
13
2020
Ion channel phosphorylopathy: a link between genomic variation and human disease
S GentileChemMedChem 7 (10), 1757-1761, 2012201
11
2012
Ion channels in aging and aging-related diseases
V Rao, S Kaja, S GentileMolecular Mechanisms of the Aging Process and Rejuvenation, 37, 2016201
10
2016
Social networking among voltage-activated potassium channels
LI Brueggemann, S Gentile, KL ByronProgress in molecular biology and translational science 117, 26-302, 2013201
9
2013
Current and potential antiarrhythmic drugs targeting voltage-gated cardiac ion channels
M Perez-Neut, VR Rao, L Haar, KW Jones, S GentileCardiol. Pharmacol 4 (139), 1-7, 2015201
6
2015
MEKK1 regulates chemokine expression in mammary fibroblasts: implications for the breast tumor microenvironment
S Gentile, N Eskandari, MA Rieger, BD CuevasFrontiers in Oncology 11, 609918, 2021202
4
2021
Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11. 1 activation in breast cancer cells and PDOs
V Senyuk, N Eskandari, Y Jiang, R Garcia-Varela, R Sundstrom, L Leanza, ...Redox Biology 5, 102030, 2021202
4
2021

Referred From: https://scholar.google.com/citations?user=wtWX0TsAAAAJ&hl=en

Cited by
Citations 1028
h-index 15
i10-index 20
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