Author

Hao Wu

Asa and Patricia Springer Professor, Boston Children's Hospital and Harvard Medical School - Cited by 38,465 - Structural biology - innate immunity - adaptive immunity - therapeutics

Biography

Dr Wu received her pre-medical training at Peking University from 1982 to 1985 and studied Medicine at Peking Union Medical College from 1985 to 1988.  She obtained her PhD degree in Biochemistry from Purdue University in 1992, working in the laboratory of Professor Michael Rossmann. Now, she is being a Senior Investigator, Program in Cellular and Molecular Medicine, Asa and Patricia Springer Professor, Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics at Harvard Medical School, USA.
Title
Cited by
Year
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
C Junqueira, Â Crespo, S Ranjbar, LB De Lacerda, M Lewandrowski, ...Nature 606 (7914), 576-584, 2022202
245
2022
Channelling inflammation: gasdermins in physiology and disease
X Liu, S Xia, Z Zhang, H Wu, J LiebermanNature reviews Drug discovery 20 (5), 384-405, 2021202
244
2021
Gasdermin D pore structure reveals preferential release of mature interleukin-1
S Xia, Z Zhang, VG Magupalli, JL Pablo, Y Dong, SM Vora, L Wang, ...Nature 593 (7860), 607-611, 2021202
223
2021
Inflammasome activation at the crux of severe COVID-19
SM Vora, J Lieberman, H WuNature Reviews Immunology 21 (11), 694-703, 2021202
184
2021
SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release
C Junqueira, Â Crespo, S Ranjbar, M Lewandrowski, J Ingber, ...Research square, 2021202
105
2021
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation
LR Hollingsworth, H Sharif, AR Griswold, P Fontana, J Mintseris, ...Nature 592 (7856), 778-783, 2021202
95
2021
NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation
L Andreeva, L David, S Rawson, C Shen, T Pasricha, P Pelegrin, H WuCell 184 (26), 6299-6312. e22, 2021202
70
2021
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome
C Shen, R Li, R Negro, J Cheng, SM Vora, TM Fu, A Wang, K He, ...Cell 184 (23), 5759-5774. e20, 2021202
68
2021
NLRP3 inflammasome assembly in neutrophils is supported by PAD4 and promotes NETosis under sterile conditions
P Münzer, R Negro, S Fukui, L Di Meglio, K Aymonnier, L Chu, ...Frontiers in immunology 12, 683803, 2021202
65
2021
Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health
TPN Bui, L Mannerås-Holm, R Puschmann, H Wu, AD Troise, B Nijsse, ...Nature Communications 12 (1), 4798, 2021202
58
2021
Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold
P Fontana, Y Dong, X Pi, AB Tong, CW Hecksel, L Wang, TM Fu, ...Science 376 (6598), eabm9326, 2022202
51
2022
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes
L Robert Hollingsworth, L David, Y Li, AR Griswold, J Ruan, H Sharif, ...Nature communications 12 (1), 189, 2021202
42
2021
Multiple domain interfaces mediate SARM1 autoinhibition
C Shen, M Vohra, P Zhang, X Mao, MD Figley, J Zhu, Y Sasaki, H Wu, ...Proceedings of the National Academy of Sciences 118 (4), e2023151118, 2021202
40
2021
Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment
H Sharif, LR Hollingsworth, AR Griswold, JC Hsiao, Q Wang, ...Immunity 54 (7), 1392-1404. e10, 2021202
38
2021
Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion
SM Vora, P Fontana, T Mao, V Leger, Y Zhang, TM Fu, J Lieberman, ...Proceedings of the National Academy of Sciences 119 (9), e2117198119, 2022202
38
2022
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
ZA Bittner, X Liu, M Mateo Tortola, A Tapia-Abellán, S Shankar, ...Journal of Experimental Medicine 218 (11), e20201656, 2021202
33
2021
Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study
N Fillmore, S Bell, C Shen, V Nguyen, J La, M Dubreuil, J Strymish, ...PloS one 16 (10), e0259061, 2021202
31
2021
Could AlphaFold revolutionize chemical therapeutics?
AB Tong, JD Burch, D McKay, C Bustamante, MA Crackower, H WuNature Structural & Molecular Biology (10), 771-772, 2021202
28
2021
TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization
W Gao, Y Li, X Liu, S Wang, P Mei, Z Chen, K Liu, S Li, XW Xu, J Gan, ...Cell Death & Differentiation 29 (2), 439-450, 2022202
26
2022
pH regulates potassium conductance and drives a constitutive proton current in human TMEM175
W Zheng, C Shen, L Wang, S Rawson, WJ Xie, C Nist-Lund, J Wu, Z Shen, ...Science advances 8 (12), eabm1568, 2022202
26
2022

Referred From: https://scholar.google.com/citations?user=mw3NTV4AAAAJ&hl=en

Cited by
Citations 38465
h-index 97
i10-index 207
Recommended Journals
Open Access Journals