Author

Ram I Mahato

Professor and Chair, Department of Pharmaceutical Sciences, University of Nebraska Medical Center - Cited by 13,815 - Drug Delivery and targeting - Gene and miRNA Therapy - Liver Fibrosis - Cancer - Diabetes

Biography

Dr. Ram Mahato’s is applying sound principles in pharmaceutical sciences in the context of the latest advances in life and material sciences to solve challenging drug delivery problems in therapeutics. Particularly, his research has provided unique insight into the design of gene delivery and expression systems, factors influencing their biodistribution and gene expression or silencing, the role of genetic modification of human islets for improved transplantation, and site-specific delivery of oligonucleotides and siRNA for treating liver fibrosis and prostate cancer.
Title
Cited by
Year
MicroRNAs in the pathogenesis and treatment of progressive liver injury in NAFLD and liver fibrosis
Q Su, V Kumar, N Sud, RI MahatoAdvanced drug delivery reviews 129, 54-63, 2018201
110
2018
Lipid-polymer hybrid nanocarriers for delivering cancer therapeutics
T Date, V Nimbalkar, J Kamat, A Mittal, RI Mahato, D ChitkaraJournal of controlled release 271, 60-73, 2018201
107
2018
Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis
V Kumar, X Xin, J Ma, C Tan, N Osna, RI MahatoAdvanced Drug Delivery Reviews 176, 113888, 2021202
48
2021
47
2019
ROS-responsive polymeric micelles for triggered simultaneous delivery of PLK1 inhibitor/miR-34a and effective synergistic therapy in pancreatic cancer
X Xin, F Lin, Q Wang, L Yin, RI MahatoACS applied materials & interfaces 11 (16), 14647-14659, 2019201
43
2019
Design of Hedgehog pathway inhibitors for cancer treatment
J Bariwal, V Kumar, Y Dong, RI MahatoMedicinal research reviews 39 (3), 1137-1204, 2019201
31
2019
Redox-responsive nanoplatform for codelivery of miR-519c and gemcitabine for pancreatic cancer therapy
X Xin, V Kumar, F Lin, V Kumar, R Bhattarai, VR Bhatt, C Tan, RI MahatoScience advances 6 (46), eabd6764, 2020202
31
2020
Impact of miRNA-mRNA profiling and their correlation on medulloblastoma tumorigenesis
V Kumar, V Kumar, AK Chaudhary, DW Coulter, T McGuire, RI MahatoMolecular Therapy-Nucleic Acids 12, 490-503, 2018201
30
2018
ApoE mimetic peptide targeted nanoparticles carrying a BRD4 inhibitor for treating Medulloblastoma in mice
Q Wang, V Kumar, F Lin, B Sethi, DW Coulter, TR McGuire, RI MahatoJournal of Controlled Release 323, 463-474, 2020202
27
2020
Cholesterol and morpholine grafted cationic amphiphilic copolymers for miRNA-34a delivery
S Sharma, S Mazumdar, KS Italiya, T Date, RI Mahato, A Mittal, D ChitkaraMolecular Pharmaceutics 15 (6), 2391-2402, 2018201
26
2018
Organic nanocarriers for delivery and targeting of therapeutic agents for cancer treatment
Y Peng, J Bariwal, V Kumar, C Tan, RI MahatoAdvanced Therapeutics 3 (2), 1900136, 2020202
21
2020
Therapeutic potential of OMe-PS-miR-29b1 for treating liver fibrosis
V Kumar, V Kumar, J Luo, RI MahatoMolecular Therapy 26 (12), 2798-2811, 181
20
2018
Nano-carriers for delivery and targeting of active ingredients of Chinese medicine for hepatocellular carcinoma therapy
M Chen, X Zhou, R Chen, J Wang, DY Richard, Y Wang, C Wu, RI MahatoMaterials Today 25, 66-87, 2019201
18
2019
Lipid based nanocarriers for effective drug delivery and treatment of diabetes associated liver fibrosis
SA Salunkhe, D Chitkara, RI Mahato, A MittalAdvanced Drug Delivery Reviews 3, 394-415, 2021202
17
2021
The use of micelles to deliver potential hedgehog pathway inhibitor for the treatment of liver fibrosis
V Kumar, Y Dong, V Kumar, S Almawash, RI MahatoTheranostics 9 (25), 7537, 2019201
17
2019
Nanoparticulate delivery of potent microtubule inhibitor for metastatic melanoma treatment
J Bariwal, V Kumar, H Chen, RS Bhattarai, Y Peng, W Li, RI MahatoJournal of Controlled Release 309, 231-243, 2019201
17
2019
Roles of microRNAs in T cell immunity: implications for strategy development against infectious diseases
BR Giri, RI Mahato, G ChengMedicinal Research Reviews 39 (2), 706-732, 2019201
14
2019
Activation of dsRNA-dependent protein kinase R by miR-378 sustains metabolic inflammation in hepatic insulin resistance
H Wang, Y Song, Y Wu, V Kumar, RI Mahato, Q SuDiabetes 70 (3), 710-719, 2021202
12
2021
Opportunities and challenges of fatty acid conjugated therapeutics
M Bhat, R Jatyan, A Mittal, RI Mahato, D ChitkaraChemistry and Physics of Lipids 236, 105053, 2021202
11
2021
Co-delivery of siAlox15 and sunitinib for reversing the new-onset of type 1 diabetes in non-obese diabetic mice
Y Peng, D Wen, F Lin, RI MahatoJournal of Controlled Release 292, 1-12, 2018201
11
2018