Author

Tanya Tolmachova

Research Fellow, Imperial College London - Cited by 4,898 - retinal pigment epithelium - ocular gene therapy - choroideremia - age-related macular degeneration

Biography

Dr Tanya Tolmachova serves as a Research Fellow at Imperial College London at the Imperial College London, England, United Kingdom. Her research interest focuses on Cell Cluster, Cell Biology and Molecular Biology.
Title
Cited by
Year
Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial
RE MacLaren, M Groppe, AR Barnard, CL Cottriall, T Tolmachova, ...The Lancet 383 (9923), 1129-1137, 2014201
823
2014
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
M Alexander, R Hu, MC Runtsch, DA Kagele, TL Mosbruger, ...Nature communications 6 (1), 7321, 2015201
676
2015
MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells
IS Okoye, SM Coomes, VS Pelly, S Czieso, V Papayannopoulos, ...Immunity 41 (1), 89-103, 2014201
552
2014
Visual acuity after retinal gene therapy for choroideremia
TL Edwards, JK Jolly, M Groppe, AR Barnard, CL Cottriall, T Tolmachova, ...New England Journal of Medicine 374 (20), 1996-1998, 2016201
208
2016
Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia
K Xue, JK Jolly, AR Barnard, A Rudenko, AP Salvetti, MI Patrício, ...Nature medicine 24 (10), 1507-2, 2018201
151
2018
Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type–specific knockout mouse models of choroideremia
T Tolmachova, ST Wavre-Shapton, AR Barnard, RE MacLaren, CE Futter, ...Investigative ophthalmology & visual science 51 (10), 4913-4920, 2010201
89
2010
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics
EM Storck, J Morales-Sanfrutos, RA Serwa, N Panyain, T Lanyon-Hogg, ...Nature chemistry 11 (6), 552-561, 2019201
86
2019
Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo
T Tolmachova, OE Tolmachov, AR Barnard, SR de Silva, DM Lipinski, ...Journal of molecular medicine 91, 825-837, 2013201
85
2013
Distinct and opposing roles for R ab27a/M lph/M yo V a and R ab27b/M unc13‐4 in mast cell secretion
RK Singh, K Mizuno, C Wasmeier, ST Wavre‐Shapton, C Recchi, SD Catz, ...The FEBS journal 280 (3), 892-903, 2013201
84
2013
Rab27-dependent exosome production inhibits chronic inflammation and enables acute responses to inflammatory stimuli
M Alexander, AG Ramstead, KM Bauer, SH Lee, MC Runtsch, J Wallace, ...The Journal of Immunology 199 (10), 3559-3570, 2017201
80
2017
PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils
KE Anderson, TAM Chessa, K Davidson, RB Henderson, S Walker, ...Blood, The Journal of the American Society of Hematology 116 (23), 4978-4989, 2010201
68
2010
Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium
ST Wavre-Shapton, T Tolmachova, ML da Silva, CE Futter, MC SeabraPloS one 8 (2), e57769, 2013201
60
2013
CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium of choroideremia mice
T Tolmachova, OE Tolmachov, ST Wavre‐Shapton, D Tracey‐White, ...The journal of gene medicine 14 (3), 158-168, 2012201
50
2012
Silencing of transgene expression: a gene therapy perspective
O Tolmachov, T Subkhankulova, T TolmachevaInTech, 2013201
32
2013
Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells
B Wankel, J Ouyang, X Guo, K Hadjiolova, J Miller, Y Liao, DKL Tham, ...Molecular biology of the cell 27 (10), 1621-1634, 2016201
29
2016
Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland
L Chiang, J Ngo, JE Schechter, S Karvar, T Tolmachova, MC Seabra, ...American Journal of Physiology-Cell Physiology 301 (2), C507-C521, 2011201
29
2011
Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland
L Chiang, J Ngo, JE Schechter, S Karvar, T Tolmachova, MC Seabra, ...American Journal of Physiology-Cell Physiology 301 (2), C507-C521, 2011201
29
2011
Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment
RK Singh, W Liao, D Tracey-White, C Recchi, T Tolmachova, SM Rankin, ...Journal of Cell Science 1 (7), 1652-1656, 2012201
25
2012
Loss of Rab27 function results in abnormal lung epithelium structure in mice
G Bolasco, DC Tracey-White, T Tolmachova, AJ Thorley, TD Tetley, ...American Journal of Physiology-Cell Physiology 300 (3), C466-C476, 2011201
17
2011
Loss of Rab27 function results in abnormal lung epithelium structure in mice
G Bolasco, DC Tracey-White, T Tolmachova, AJ Thorley, TD Tetley, ...American Journal of Physiology-Cell Physiology 300 (3), C466-C476, 2011201
17
2011

Referred From: https://scholar.google.com/citations?user=k2RmCxIAAAAJ&hl=en

Cited by
Citations 4898
h-index 29
i10-index 39
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