Author

Ryuhei Hayashi

Osaka University Graduate School of Medicine, Stem Cells and Applied Medicine - Cited by 1,727 - Stem cell biology - Regenerative medicine - Developmental biology

Biography

We are working on ocular cell development using pluripotent stem cells and recently have generated "whole eye organoids" containing corneal, retinal cells and lentoids et al. from human PSCs (Hayashi R. et al. 2016). Furthermore, we've developed a new therapeutic strategy for corneal regeneration using human iPSCs as a cell source. And we also work on the mechanism of ocular cell development based on ECM-mediated signal transduction.
Title
Cited by
Year
Co-ordinated ocular development from human iPS cells and recovery of corneal function
R Hayashi, Y Ishikawa, Y Sasamoto, R Katori, N Nomura, T Ichikawa, ...Nature 531 (7594), 376-380, 2016201
221
2016
Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells
R Hayashi, Y Ishikawa, R Katori, Y Sasamoto, Y Taniwaki, H Takayanagi, ...Nature Protocols 12 (4), 683-696, 2017201
87
2017
PAX6 isoforms, along with reprogramming factors, differentially regulate the induction of cornea-specific genes
Y Sasamoto, R Hayashi, SJ Park, M Saito-Adachi, Y Suzuki, S Kawasaki, ...Scientific reports 6 (1), 20807, 2016201
49
2016
Selective laminin-directed differentiation of human induced pluripotent stem cells into distinct ocular lineages
S Shibata, R Hayashi, T Okubo, Y Kudo, T Katayama, Y Ishikawa, J Toga, ...Cell reports 25 (6), 1668-1679. e5, 2018201
44
2018
CD200 facilitates the isolation of corneal epithelial cells derived from human pluripotent stem cells
R Hayashi, Y Ishikawa, T Katayama, AJ Quantock, K NishidaScientific Reports 8 (1), 16550, 2018201
25
2018
A self-assembling peptide gel as a vitreous substitute: a rabbit study
K Uesugi, H Sakaguchi, Y Hayashida, R Hayashi, K Baba, Y Suganuma, ...Investigative Ophthalmology & Visual Science 58 (10), 4068-4075, 2017201
23
2017
KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF-β2 suppression
S Fujimoto, R Hayashi, S Hara, Y Sasamoto, J Harrington, M Tsujikawa, ...Regenerative Therapy 11, 249-257, 2019201
22
2019
The secretome of adipose-derived mesenchymal stem cells attenuates epithelial–mesenchymal transition in human corneal epithelium
S Shibata, R Hayashi, T Okubo, Y Kudo, K Baba, Y Honma, K NishidaRegenerative therapy 11, 114-122, 2019201
18
2019
Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs
K Nomi, R Hayashi, Y Ishikawa, Y Kobayashi, T Katayama, AJ Quantock, ...Cell Reports 34 (5), 2021202
15
2021
Localization and osteoblastic differentiation potential of neural crest-derived cells in oral tissues of adult mice
M Ono, T Suzawa, M Takami, G Yamamoto, T Hosono, A Yamada, ...Biochemical and biophysical research communications 464 (4), 1209-12, 2015201
14
2015
Ocular surface ectoderm instigated by WNT inhibition and BMP4
Y Kobayashi, R Hayashi, S Shibata, AJ Quantock, K NishidaStem Cell Research 46, 101868, 2020202
14
2020
Spontaneous acquisition of infinite proliferative capacity by a rabbit corneal endothelial cell line with maintenance of phenotypic and physiological characteristics
T Kageyama, R Hayashi, S Hara, K Yoshikawa, Y Ishikawa, M Yamato, ...Journal of Tissue Engineering and Regenerative Medicine 11 (4), 1057-1064, 2017201
12
2017
Chondroitin sulfate as a potential modulator of the stem cell niche in cornea
S Ashworth, J Harrington, GM Hammond, KK Bains, E Koudouna, ...Frontiers in Cell and Developmental Biology 8, 567358, 2021202
12
2021
Generation of knockout rabbits with X-linked severe combined immunodeficiency (X-SCID) using CRISPR/Cas9
Y Hashikawa, R Hayashi, M Tajima, T Okubo, S Azuma, M Kuwamura, ...Scientific Reports 10 (1), 9957, 2020202
12
2020
Generation of 3D lacrimal gland organoids from human pluripotent stem cells
R Hayashi, T Okubo, Y Kudo, Y Ishikawa, T Imaizumi, K Suzuki, S Shibata, ...Nature 605 (7908), 126-131, 2022202
11
2022
Method for preparing corneal endothelial cell
R Hayashi, S Hara, T Kageyama, K NishidaUS Patent 9,347,041, 2016201
11
2016
Cell-type-specific adhesiveness and proliferation propensity on laminin isoforms enable purification of iPSC-derived corneal epithelium
S Shibata, R Hayashi, Y Kudo, T Okubo, T Imaizumi, T Katayama, ...Stem Cell Reports 14 (4), 663-676, 2020202
10
2020
High-resolution promoter map of human limbal epithelial cells cultured with keratinocyte growth factor and rho kinase inhibitor
M Yoshihara, Y Sasamoto, R Hayashi, Y Ishikawa, M Tsujikawa, ...Scientific Reports 7 (1), 2845, 2017201
10
2017
Ebselen preserves tissue-engineered cell sheets and their stem cells in hypothermic conditions
R Katori, R Hayashi, Y Kobayashi, E Kobayashi, K NishidaScientific Reports 6 (1), 38987, 2016201
10
2016
A new in vitro model of GDLD by knocking out TACSTD2 and its paralogous gene EpCAM in human corneal epithelial cells
P Xu, C Kai, S Kawasaki, Y Kobayashi, K Yamamoto, M Tsujikawa, ...Translational Vision Science & Technology 7 (6), 30-30, 20120
8
2018

Referred From: https://scholar.google.co.jp/citations?user=jdAYG84AAAAJ&hl=ja

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Citations 1727
h-index 22
i10-index 38
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